Main
Mickaël Canouil
Curriculum Vitæ
I’m currently working for the Institut Pasteur de Lille at the Inserm U1283 / CNRS UMR 8199 - “Functional (Epi)genomics and Molecular Physiology of Diabetes and Related Diseases” as the head of the biostatistics team.
Education
Doctor of Philosophy (Ph.D.) in Biostatistics
University of Lille
Lille, France
Oct. 2014 - Sep. 2017
Thesis: Development and Application of Statistical Methods for Multi-Omics Studies in Type 2 Diabetes: Beyond the Genome-Wide Association Studies Era
Master’s Degree in Biostatistics, Bioinformatics and Genomics (Specialised in Biostatistics)
University Claude Bernard Lyon 1
Lyon, France
Sep. 2009 - Jul. 2011
Internships:
- Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward (3 months)
- Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data (6 months)
Bachelor’s Degree in Biology (Specialised in Biostatistics)
University Claude Bernard Lyon 1
Lyon, France
Sep. 2006 - Jul. 2009
Professional & Research Experience
Head of the Biostatistics Team (Institut Pasteur de Lille)
Functional (Epi)genomics and Molecular
Physiology of Diabetes and Related Diseases
Inserm U1283 / CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Jan. 2020 - Present
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management
Head of the Biostatistics Team (Institut Pasteur de Lille)
Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Oct. 2017 - Dec. 2019
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management
Head of the Biostatistics Team (CNRS)
Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Jan. 2016 - Sep. 2017
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments, team management
Biostatistician (CNRS)
Laboratory of Integrated Genomics
and Metabolic Diseases Modeling
CNRS UMR 8199 - EGID
(European Genomics Institute for Diabetes)
Lille, France
Sep. 2012 - Dec. 2015
Activities: Genome-wide association studies, experimental design, -omics data analysis, methodological developments
Biostatistician
French Institute of Science and Technology for
Transport, Development and Networks
(IFSTTAR)
UMRESTTE - UMR T9405
Bron, France
Nov. 2011 - Dec. 2011
Activities: Analysis of a mobility and accident study in secondary-school pupils
Biostatistician (Internship)
Hospices Civiles de Lyon
Biostatistics Unit
CNRS UMR 5558
Lyon, France
Jan. 2011 - Jun. 2011
Activities: Development of a Non-Parametric (on Time) Clustering Algorithm for Longitudinal Data
Biostatistician (Internship)
Biometry and Evolutionary Biology laboratory
(LBBE)
CNRS UMR 5558
Lyon, France
Mar. 2010 - Jun. 2010
Activities: Mathematical Modelling of Nosocomial Rotavirus Infections in Pediatric Ward
Workshop Experience (6)
Awards (1)
Funding Allocation SFD-Lilly
“Société Francophone du Diabète”
(SFD)
Bordeaux, France
Mar. 2015
Project: Detection of new genomic variants associated with fasting blood glucose and incidence of type 2 diabetes simultaneously
Oral communications (3)
Jointly Modelling SNPs With Survival & Longitudinal Trait
A Statistical Seminar Applied on Type 2 Diabetes (Host: Pr. Paul Franks)
Lund, Sweden
Jan. 2019
Jointly Modelling SNPs With Survival & Longitudinal Trait
Thematic Day “Statistic & Genomic”
of the “Réseau Interdisciplinaire
autour de la Statistique”
(RIS)
Paris, France
Oct. 2018
Longitudinal Genetic Modelling: Revisiting Associations of SNPs Associated With Blood Fasting Glucose in Normoglycemic Individuals
Statistical Methods for Post Genomic Data
(SMPGD)
Lille, France
Feb. 2016
Poster communications (4)
“Variants Génétiques Associés à la Trajectoire de la Glycémie à Jeun et à l’Incidence du Diabète de Type 2: Une Approche par Modèle Joint” (CA-075)
Annual Congress of
“Société Francophone du Diabète”
(SFD)
Lille, France
Mar. 2017
Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach
4th Symposium
European Genomic Institute for Diabetes
(EGID)
Lille, France
Nov. 2016
Single Nucleotide Polymorphisms Associated With Fasting Blood Glucose Trajectory And Type 2 Diabetes Incidence: A Joint Modelling Approach
International Genetic Epidemiology Society
(IGES)
Toronto, Canada
Oct. 2016
Application of Joint Models in Genetic Association Studies
International Genetic Epidemiology Society
(IGES)
Baltimore, United-States
Oct. 2015
R Packages (10)
insane: An Interactive Web Application for Quality Control and Analysis of Insulin Secretion from Pancreatic Beta Cells
(As author / creator)
CRAN
Nov. 2020
https://cran.r-project.org/package=insane
https://github.com/mcanouil/insane/
ggpacman: A ‘ggplot2’ and ‘gganimate’ Version of Pac-Man
(As author / creator)
CRAN
May 2020
https://cran.r-project.org/package=ggpacman
https://github.com/mcanouil/ggpacman/
dmapaq: DNA Methylation Arrays Processing And Quality-Control
(As author / creator)
GitHub
Mar. 2020
dgapaq: DNA Genotyping Arrays Processing And Quality-Control
(As author / creator)
GitHub
Mar. 2020
ggnetwork: Geometries to Plot Networks with ‘ggplot2’
(As contributor)
CRAN
Feb. 2020
https://cran.r-project.org/package=ggnetwork
https://github.com/briatte/ggnetwork/
rain: Reference-based Ancestry Inference
(As author / creator)
GitHub
Jan. 2020
MiSTr: Mixed effects Score Test
(As contributor / creator)
GitHub
Nov. 2019
NACHO: NanoString Quality Control Dashboard
(As author / creator)
CRAN
Jun. 2018
https://cran.r-project.org/package=NACHO
https://github.com/mcanouil/NACHO/
clere: Simultaneous Variables Clustering and Regression
(As author)
CRAN
Feb. 2014
https://cran.r-project.org/package=clere
https://github.com/mcanouil/clere/
snpEnrichment: SNPs Enrichment Analysis
(As author / creator)
CRAN
Apr. 2013
https://cran.r-project.org/package=snpEnrichment
https://github.com/mcanouil/snpEnrichment/
Publications (31)
Chromatin 3D Interaction Analysis of the STARD10 Locus Unveils FCHSD2 as a Regulator of Insulin Secretion
Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, […], Mickaël Canouil7/18, […], Paul J. Gadue, Benoit Hastoy, Leonardo Alemeida-Souza, Harvey McMahon and Guy A. Rutter
N/A
Feb. 2021
Monogenic Diabetes Characteristics in a Transnational Multicenter Study From Mediterranean Countries
Martine Vaxillaire, Amélie Bonnefond, Stavros Liatis, Leila Ben Salem Hachmi, Aleksandra Jotic, […], Mickaël Canouil11/24, […], Doros Loizou, Nebojsa Lalic, Josanne Vassallo, Michel Marre and Philippe Froguel
N/A
Nov. 2020
Pathogenic Variants in Actionable MODY Genes are Associated with Type 2 Diabetes
Amélie Bonnefond, Mathilde Boissel, Alexandre Bolze, Emmanuelle Durand, Bénédicte Toussaint, […], Martine Vaxillaire, Mickaël Canouil24/27, Nicole L. Washington, Joseph J. Grzymski and Philippe Froguel
N/A
Oct. 2020
Gene-Educational Attainment Interactions in a Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci
Lifelines Cohort Study, Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, […], Mickaël Canouil75/223, […], Paul Elliott, Patricia B. Munroe, Paul W. Franks, Dabeeru C. Rao and Myriam Fornage
N/A
May 2020
General Regression Model: A “Model-Free” Association Test for Quantitative Traits Allowing to Test for the Underlying Genetic Model
Emilie Gloaguen, Marie-Hélène Dizier, Mathilde Boissel, Ghislain Rocheleau, Mickaël Canouil5/11, […], Jean Tichet, Ronan Roussel, Cécile Julier, Beverley Balkau and Flavie Mathieu
N/A
Dec. 2019
Loss-of-Function Mutations in MRAP2 Are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension
Morgane Baron, Julie Maillet, Marlène Huyvaert, Aurélie Dechaume, Raphaël Boutry, […], Mehdi Derhourhi, Stefan Gaget, Mickaël Canouil29/31, Philippe Froguel and Amélie Bonnefond
N/A
Nov. 2019
The Expression of Genes in Top Obesity-Associated Loci Is Enriched in Insula and Substantia Nigra Brain Regions Involved in Addiction and Reward
Fatou K. Ndiaye, Marlène Huyvaert, Ana Ortalli, Mickaël Canouil4/17, Cécile Lecoeur, […], Michel Marre, Ronan Roussel, Beverley Balkau, Philippe Froguel and Amélie Bonnefond
N/A
Aug. 2019
NACHO: An R package for Quality Control of NanoString nCounter Data
Mickaël Canouil†, Gerard A. Bouland, Amélie Bonnefond, Philippe Froguel, Leen M. ’t Hart and Roderick C. Slieker
N/A
Aug. 2019
† As first or co-first author.
Genome-Wide Association Study of Change in Fasting Glucose Over Time in 13,807 Non-Diabetic European Ancestry Individuals
Ching-Ti Liu, Jordi Merino, Denis Rybin, Daniel DiCorpo, Kelly S. Benke, […], Mickaël Canouil7/50, […], Inês Barroso, Inga Prokopenko, Josée Dupuis, James B. Meigs and Nabila Bouatia-Naji
N/A
Jul. 2019
A Trans-Ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity
Jonathan P. Bradfield, Suzanne Vogelezang, Janine F. Felix, Alessandra Chesi, Øyvind Helgeland, […], Mickaël Canouil41/99, […], Nicholas J. Timpson, Stefan Johansson, Hakon Hakonarson, Vincent W. V. Jaddoe and Struan F. A. Grant
N/A
Jul. 2019
A Catalog of Genetic Loci Associated with Kidney Function From Analyses of a Million Individuals
Matthias Wuttke, Yong Li, Man Li, Karsten B. Sieber, Mary F. Feitosa, […], Mickaël Canouil51/327, […], Iris M. Heid, Markus Scholz, Alexander Teumer, Anna Köttgen and Cristian Pattaro
N/A
Jun. 2019
Multi-Ancestry Genome-Wide Gene–Smoking Interaction Study of 387,272 Individuals Identifies New Loci Associated with Serum Lipids
Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, […], Mickaël Canouil97/301, […], Patricia B. Munroe, Alanna C. Morrison, Dabeeru C. Rao, Charles N. Rotimi and L. Adrienne Cupples
N/A
Apr. 2019
A Multi-Ancestry Genome-Wide Study Incorporating Gene-Smoking Interactions Identifies Multiple New Loci for Pulse Pressure and Mean Arterial Pressure
Yun Ju Sung, Lisa de las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, […], Mickaël Canouil95/282, […], Mark J. Caulfield, W. James Gauderman, Patricia B. Munroe, Dabeeru C. Rao and Alanna C. Morrison
N/A
Apr. 2019
Laser Capture Microdissection of Human Pancreatic Islets Reveals Novel eQTLs Associated with Type 2 Diabetes
Amna Khamis, Mickaël Canouil†2/20, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, […], Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena and Philippe Froguel
N/A
Mar. 2019
† As first or co-first author.
Multi-Ancestry Study of Blood Lipid Levels Identifies Four Loci Interacting with Physical Activity
Lifelines Cohort Study, Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Yun Ju Sung, […], Mickaël Canouil75/230, […], L. Adrienne Cupples, Charles N. Rotimi, Alanna C. Morrison, Dabeeru C. Rao and Ruth J. F. Loos
N/A
Jan. 2019
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
Paul S. de Vries, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil81/266, […], Kenneth Rice, Daniel I. Chasman, L. Adrienne Cupples, Dabeeru C. Rao and Alanna C. Morrison
N/A
Jan. 2019
Fine-Mapping Type 2 Diabetes Loci to Single-Variant Resolution Using High-Density Imputation and Islet-Specific Epigenome Maps
Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, […], Mickaël Canouil35/115, […], Kari Stefansson, Anna L. Gloyn, Andrew P. Morris, Michael Boehnke and Mark I. McCarthy
N/A
Oct. 2018
Type 2 Diabetes–Associated Variants of the MT2 Melatonin Receptor Affect Distinct Modes of Signaling
Angeliki Karamitri, Bianca Plouffe, Amélie Bonnefond, Min Chen, Jonathan Gallion, […], Mickaël Canouil9/17, […], Viktoria Lukasheva, Olivier Lichtarge, Philippe Froguel, Michel Bouvier and Ralf Jockers
N/A
Aug. 2018
Jointly Modelling Single Nucleotide Polymorphisms with Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose
Mickaël Canouil†, Beverley Balkau, Ronan Roussel, Philippe Froguel and Ghislain Rocheleau
N/A
Jun. 2018
† As first or co-first author.
Novel Genetic Associations for Blood Pressure Identified via Gene-Alcohol Interaction in up to 570K Individuals Across Multiple Ancestries
Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, […], Mickaël Canouil87/274, […], Mark J. Caulfield, Patricia B. Munroe, Dabeeru C. Rao, Michael A. Province and Daniel Levy
N/A
Jun. 2018
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes
Amar Abderrahmani, Loïc Yengo, Robert Caiazzo, Mickaël Canouil†4/38, Stéphane Cauchi, […], Clemens Schafmayer, Jochen Hampe, Amélie Bonnefond, François Pattou and Philippe Froguel
N/A
May 2018
† As first or co-first author.
Refining the Accuracy of Validated Target Identification Through Coding Variant Fine-Mapping in Type 2 Diabetes
Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, […], Mickaël Canouil68/243, […], Michael Boehnke, Danish Saleheen, Andrew P. Morris, Jerome I. Rotter and Mark I. McCarthy
N/A
Apr. 2018
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Yun J. Sung, Thomas W. Winkler, Lisa de Las Fuentes, Amy R. Bentley, Michael R. Brown, […], Mickaël Canouil94/301, […], Patricia B. Munroe, Alanna C. Morrison, L. Adrienne Cupples, Dabeeru C. Rao and Daniel I. Chasman
N/A
Mar. 2018
Expression and Functional Assessment of Candidate Type 2 Diabetes Susceptibility Genes Identify Four New Genes Contributing to Human Insulin Secretion
Fatou K. Ndiaye, Ana Ortalli, Mickaël Canouil†3/22, Marlène Huyvaert, Clara Salazar-Cardozo, […], Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel and Amélie Bonnefond
N/A
Jun. 2017
† As first or co-first author.
Low-Dose Exposure to Bisphenols A, F and S of Human Primary Adipocyte Impacts Coding and Non-Coding RNA Profiles
Marie Verbanck, Mickaël Canouil†, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, Loïc Yengo, Philippe Froguel and Odile Poulain-Godefroy
N/A
Jun. 2017
† As first or co-first author.
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice
Gaelle R. Carrat, Ming Hu, Marie-Sophie Nguyen-Tu, Pauline Chabosseau, Kyle J. Gaulton, […], Mickaël Canouil10/26, […], Anna L. Gloyn, Philippe Froguel, Michele Solimena, Mark I. McCarthy and Guy A. Rutter
N/A
Feb. 2017
Relationship Between Salivary/Pancreatic Amylase and Body Mass Index: A Systems Biology Approach
Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil4/20, Maxime Castelain, […], Beverley Balkau, Michel Marre, François Pattou, Thierry Brousseau and Philippe Froguel
N/A
Feb. 2017
Hepatic DPP4 DNA Methylation Associates with Fatty Liver
Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, […], Mickaël Canouil7/17, […], Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann and Robert W. Schwenk
N/A
Jan. 2017
Variable Clustering in High-Dimensional Linear Regression: The R Package
Loïc Yengo, Julien Jacques, Christophe Biernacki and Mickaël Canouil
N/A
Apr. 2016